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One step ahead.

Working side-by-side with leading foot & ankle surgeons, we identified the need for intelligently designed solutions, from intuitive implant systems to clinically advanced orthobiologics. Together, we stepped up to the challenge and created Medline UNITE, an innovative portfolio of products and technology, thoughtfully designed to meet the unique needs of foot and ankle surgery.


Add the unique benefits of hyaluronic acid
to your surgical toolbox.



Hyaluronic acid (HA) is a major biochemical difference between fetal and adult wound environments. Hyalomatrix puts HA’s innate tissue regeneration properties in your skilled hands, helping you bring new hope to patients and their families. It features esterified HYAFF, an exceptionally long-lasting form of HA. HYAFF delivers HA to the wound bed in a prolonged manner, facilitating each stage of the healing process.1-5


, Hyalomatrix

Provides the foundation for skin grafting and re-epithelialization.

Facilitates cellular infiltration by using an open scaffold—no cross-linking.6


, Hyalomatrix

Helps reduce infection risk.

Rebuilds a well-vascularized neodermis as fast as possible, helping protect your patients from infection.1,3,7,8,9


, Hyalomatrix

Promotes quality healing.

Provides an adequate wound bed for healing by successful grafting or secondary intention, which may help reduce patient discomfort and hospital stay.1,7,9




Mechanisms of action


The HYAFF technology behind Hyalomatrix is based on hyaluronic acid rather than collagen, making it unique among skin substitutes.


Hydrodynamic effect
HA binds 1,000 times its weight in water. This helps facilitate cellular migration and creates water-rich space that helps organize collagen, which is key to reducing scar tissue formation.10, 11


Biological effect
HA facilitates an increase in pro-inflammatory cytokines, activating and recruiting native cells—including endothelial cells and fibroblasts.12,13


Scaffolding effect
Presented as fibers, the HYAFF serves as a scaffold, giving the patient’s native cells a place to live, thrive and rebuild tissue. Without cross-linking, the open scaffold allows for cellular infiltration and capillary growth.6

Recommended Wound Types


Hyalomatrix consists of two layers: a non-woven pad of esterified HYAFF and a semi-transparent silicone membrane. It’s recommended for:

  • Surgical wounds
  • Large, full-thickness wounds
  • Burns/traumas
  • Graft sites


  • Pressure, venous, diabetic ulcers
  • Chronic vascular ulcers
  • Tunneled/undermined wounds
  • Trauma wounds (abrasions, lacerations skin tears)
  • Partial- and full-thickness wounds
  • Second-degree burns
  • Draining wounds
  • Surgical wounds (donor sites,/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence)


Individuals with a hypersensitivity to hyaluronan and/or its derivatives, or silicone.


1. Caravaggi C, Grigoletto F, Scuderi N. Wound Bed Preparation With a Dermal Substitute (Hyalomatrix® PA) Facilitates Re-epithelialization and Healing: Results of a Multicenter, Prospective, Observational Study on Complex Chronic Ulcers (The FAST Study). WOUNDS 2011;23(8):228–235. Available at: Accessed June 18, 2018.
2. Voigt J, Driver VR. Hyaluronic Acid Derivatives and Their Healing Effect on Burns, Epithelial Surgical Wounds, and Chronic Wounds: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Wound Repair Regen. 2012 May-Jun;20(3):317-31. Available at: Accessed June 18, 2018.
3. Gravante G, Sorge R, Merone A, et al. Hyalomatrix PA in Burn Care Practice: Results From a National Retrospective Survey, 2005–2006. Ann Plast Surg. 2010;64(1):69–79.
4. Longinotti C. The Use of Hyaluronic Acid-Based Dressings to Treat Burns: A Review. Burn Trauma [Epub ahead of print] [cited 2014 Oct 16]. Available from: Accessed June 20, 2018.
5. Moseley R, Walker M, Waddington RJ, Chen WYJ. Comparison of the Antioxidant Properties of Wound Dressing Materials–Carboxymethylcellulose, Hyaluronan Benzyl Ester and Hyaluronan, Towards Polymorphonuclear Leukocyte-Derived Reactive Oxygen Species. Biomaterials (Impact Factor: 8.31). 05/2003; 24(9):1549-57.
6. Pasquinelli G, Vinci MC, Gamberini C, et al. Architectural Organization and Functional Features of Early Endothelial Progenitor Cells Cultured in a Hyaluronan-Based Polymer Scaffold. Tissue Eng Part A. 2009;15(9):2751–62.
7. Gravante G, Delogu D, Giordan N, et al. The Use of Hyalomatrix PA in the Treatment of Deep Partial-Thickness Burns. Jour Burn Care Res. 2007;28(2):269-74.
8. Caravaggi C, Barbara A, Sganzaroli A, et al. Safety and Efficacy of a Dermal Substitute in the Coverage of Cancellous Bone After Surgical Debridement for Severe Diabetic Foot Ulceration. EWMA J. 2009;9(1):11–4.
9. Simman R, Mari W, Younes S and Wilson M. Use of Hyaluronic Acid-Based Biological Bilaminar Matrix in Wound Bed Preparation: A Case Series. ePlasty. 2018; 18:e10. Available at: . Accessed June 18, 2018.
10. Erbatur S, Coban YK, Aydın EN. Comparision of Clinical and Histopathological Results of Hyalomatrix Usage in Adult Patients. Intl Jour Burns and Trauma. 2012;2(2):118-125. Available at: . Access June 18, 2018.
11. Frenkel JS. The Role of Hyaluronic Acid in Wound Healing. Intl Wound Jour. 2014;11:159-163. Available at: . Accessed June 18, 2018.
12. Litwiniuk M, Krejner A, Grzela T. Hyaluronic Acid in Inflammation and Tissue Regeneration. Wounds. 2016;28(3):78-88. Available at: . Accessed June 20, 2018.
13. Fakhari A, Berkland C. Applications and Emerging Trends of Hyaluronic Acid in Tissue Engineering, as a Dermal Filler, and in Osteoarthritis Treatment. Acta biomaterialia. 2013;9(7):7081-7092. Available at: . Accessed July 11, 2018.

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